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Research Facilities | |
Most of the essential research facilities including glasshouse are available to carry out pathological work at molecular level.
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Significant Achievements | |
(i) Bioactivity guided extraction and isolation of marker phytochemicals- Employing modern chromatographic techniques, viz.: CC, TLC, Flash, and HPLC, etc. Some of the notable achievements are- • Anti-cancer (Arjunic acid) •Hepatoprotectives (Phyllanthus lignans) •Immunomodulators (Lupeol, ursolic acid) •Anti-psychotic (Indole alkaloids), /span> •Anti-filarial (Diarylheptanoids); •Anti-ageing (Iridoids); •Anti-inflammatory (Erandone) •Anti-tubercular (Diterpenoids, curcuminoids), •Anti-inflammatory (Erandone) •Anti-malarial (Phloridzin, phloretin, taraxasterol derivatives,)
(ii)Standardization of Raw herbs and their derived products • Development of chemical fingerprinting and analytical/ noninvasive techniques of phytomolecules by HPTLC, HPLC-PDA, HPLC-MS and HPLC-MS-MS, GC, GC-MS, NIR, etc. More than 40 standard operating procedures (SOPs) for medicinal plants used in traditional system of medicine e.g. Withania, Arjuna, Brahmi, Andrographis, Catharanthus,Senna, Rasana, Rauwolfia etc. were developed. • Defined the Chemotype of plant varieties developed at CIMAP (medicinal plants-26/ Aromatic crop-23) e.g. Withania somnifera, A. annua, Silybum marianum, etc • More than 25 New Chemical Entities (NCEs) as marker chemicals for quality assurance of medicinal plants • Developed more than 125 Botanical Reference substance (BRSCIMAP) for quick authentication of raw and powdered herbs. • Defined Standards for Indian Pharmacopeia -Terminalia arjuna & Artemisia annua and Artemisinin ; • Developed SOPs for quality assurance of CIMAP herbal products.
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