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Last Updated: Thursday, 18 October 2018
| Molecules and bioactivities | ||||
| S.No | Title | Inventors and Team | Country/Patent No./Grant Date | Summary |
| 1 |
Method for the use of alpha artheether as an anti-bacterial and anti-fungal agent |
Sushil Kumar, |
US/6127405/3.10.2000 | The invention relates to the novel use of alpha-arteether as an advanced generation antibacterial and antifungal agent, preferably for bacteria, which are resistant to quinolone drugs due to mutations in DNA gyrase gene |
| 2 | Benzylidene indanones and processes for preparation and use thereof | AS Negi, AP Prakasham, AK Saxena, S Luqman, D Chanda, Tandeep Kaur, Atul Gupta |
US/8633242/21.1.2014 India/291668/12.01.2018
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The invention relates to the potent anticancer and tubulin polymerization inhibition activity of new benzylidene indanones synthesized from gallic acid against several human cancer cell lines. The invention also provides a new process for the preparation of the said molecules and testing these for in vitro cytotoxic activity against various human cancer cell lines using Sulphorhodamine B Assay. Compounds were evaluated for acute oral activity in Swiss albino mice and were found to be safe up to 300mg/kg body weight. |
| 3 | A novel plant growth promoting naphthophenone derivative from gallic acid | AS Negi, MP Darokar, SPS Khanuja, SK Chattopadhyay, Ankur Garg, Togarrati Padmapriya, Sachin Srivastava, AK Shasany, AK Bhattacharya, |
SouthAfrica/2006/5368/26.8.2008 India/250039/30.11.2011 |
This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule Methanone- (3', 4', 5'-trimethoxy) phenyl, 1-naphthyl, 2-O-4'-ethyl but-2'-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having the structural formulae (1) and molecular formulae C26H26O7. This invention also provides a novel process for preparation of a said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al 2001). |
| 4 | A new nitrile glycoside useful as a bioenhancer of drugs and nutrients and the process of its isolation from Moringa oleifera | SPS Khanuja, JS Arya, TRS Kumar, D Saikia, HS Kaur, Monika Singh, SC Gupta, AK Shasany, MP Darokar, SK Srivastava, MM Gupta, SC Verma, Anirban Pal |
Germany/1611148/5.11.2008
US/6858588/22.2.2005 SouthAfrica/2005/07911/29.11.2006/ India/234974/23.6.2009 |
The invention relates to a novel nitrile glycoside named NIAZIRIDIN and the analogues and derivatives thereof by bioactivity-guided fractionation from the pods of Moringa oleifera in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (-) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore, niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy. |
| 5 | Use of phyllocladane diterpenoids for plant growth promotion and alleviation of growth retardant allelochemicals | AK Singh, GD Bagchi, Sarita Singh, PD Dwivedi, AK Gupta, SPS Khanuja |
Australia/2002348820/14.2.2007
US/6673749/6.1.2004 |
The invention provides plant growth-promoting activities of active plant constituent calliterpenone and its derivatives belonging to the group phyllocladane diterpenoids. These phytochemicals and derivatives exhibit remarkable growth promoting activities on plant roots, shoots and promote seed germination both in mono and dicotyledonous plants. These phytomolecule possess antagonistic activity against allelochemicals of plant growth retardant nature and hence can be used to alleviate their detrimental effects. |
| 6 | Use of the root extract of Vetiveria zizanioides in curing fluoroquinolone and multi drug resistant bacterial infections |
SPS Khanuja,
Suchi Srivastava,
TRS Kumar,
MM Gupta,
AK Tripathi,
Monika Singh,
JR Bahl,
RK Lal,
MP Darokar,
AK Shasany,
Sushil Kumar
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Canada/2480284/30.6.2013 USA/6676974/13.1.2004
India/218190/31.3.2008
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The present invention relates to a hexane bioactive fraction obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug-resistant bacterial infections in humans and animals. It also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug-resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract. |
| 7 |
a-yohimbine and its derivatives as antipsychotic agents and process of their preparation |
SK Srivastava, |
India/281936/29.3.2017 |
The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. QSAR model showed activity-descriptors relationship correlating measure (r2) 0.87 (87%) and predictive accuracy of 81% (rCV2=0.81). The present invention specifically showed strong binding affinity of the untested (unknown) novel compounds against anti-psychotic targets viz., Dopamine D2 and Serotonin (5HT2A) receptors through molecular docking approach. The present invention further showed compliance of Lipinski's rule of five for oral bioavailability and toxicity risk assessment for all the active Yohimbine derivatives |
| 8 | Novel antipsychotic activity in the leaf extracts of Rauwolfia tetraphylla and their useful herbal formulations |
SK Srivastava, |
Australia/2010231489/8.1.2015
US/9018226/28.4.2015 |
The invention relates to novel antipsychotic activity in the leaf extracts of Rauwolfia tetraphylla and their useful herbal formulations for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and serotonergic (5HT2A) receptors for antipsychotic activity. The invention also provides a process for obtaining antipsychotic extracts from the leaves of Rauwolfia tetraphylla, which are non-toxic and devoid of extra pyramidal side effects. |
Last Updated: Tuesday, 11 July 2017
| Publications | |
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Natural Products Chemistry Group Research Publications 1. New constituents from Psoralea corylifolia. 2. New anti-inflammatory triterpene from the root of Ricinus communis 4. In-vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. 6. Anti-Helicobacter pylori potential of artemisinin and its derivatives. 7. Synthesis, antitubercular activity, and molecular modeling studies of analogues of isoliquiritigenin and liquiritigenin, bioactive components from Glycyrrhiza glabra. |
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| Medicinal Chemistry Group Research Publications | |
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Antimalarials 1. Hairy root mediated functional derivatization of artemisinin and their bioactivity analysis. 2. In-vitro antimalarial studies of novel artemisinin biotransformed products and its derivatives. 3. In-vitro antimalarial activity and molecular modelling studies of novel artemisinin derivatives. Anticancer 2. 2-(3´, 4´-Dimethoxybenzylidene) tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species.. 3. Anticancer activity and toxicity profiles of 2-benzylidene indanone lead Molecule. 4. Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. 5.Synthesis of combretastatin A4 analogues on steroidal framework and their anti-breast cancer activity.
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Last Updated: Tuesday, 11 July 2017
| Opportunities at Chemical Sience Division | |
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As a young researcher one can find explore the innovative and exciting research by joining us – Doctoral Research Program CSIR-CIMAP invites eligible candidate to conducts research for the award of PhD degree. The students pursuing doctoral research have the option for Ph. D. degree registration either from AcSIR or from Jawaharlal Nehru University, New Delhi. The division has all expertise and essential resources and to carry out research in the emerging mission areas of drug development and industrial partnering. With substantial funding from government and industrially sponsored projects, our research interests are multidisciplinary focused on diverse topics such as Natural Products Chemistry, Medicinal/Pharmaceutical Chemistry, Analytical/Bio-analytical, Synthetic Chemistry and Process Chemistry. Chemical Sciences Division is looking forward to young, enthusiastic and intellectual research students to shape their career and to realise their dreams. For update visit www.cimap.res.in Graduate Training Program CSIR-CIMAP invites eligible students of Masters degree programme (MPharm & MSc) of universities and institute’s for the completion of required 6-10month research project in the area of Natural Products Chemistry, Industrial Chemistry, Pharmaceutical Chemistry, Pharmacognosy, Pharmacutical analysis, Synthetic chemistry etc. Please visit our website and apply through given weblink- http://14.139.57.217/cimaphrd/RegistrationInsturctions.aspx Postdoctoral Research Program Government of India provide financial support to young and brilliant scholar to conduct quality research through number of options eg. Sponsored funding, fellowship (DST N-PDF, WOS-A/B, TWAS-DBT) etc. Interested candidate may join us. Training and Workshops CSIR-CIMAP organise Advanced Instrumentation and Analytical Training Programme every year. The detail programme and fee will be announced in due course of time. Please visit Institute website- http://www.cimap.res.in/english/index.php/notice-board/trainings Analytical Services CSIR-CIMAP offers analytical services to the research scholars, enterprenurers, and farmers on nominal charge basis. For detail information visit http://www.cimap.res.in/english/images/AboutUs/services/pricelistHPLC.pdf |
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Last Updated: Wednesday, 24 October 2018
| Cell Culture Strain | ||||
| S.No | Title | Inventors and Team | Country/Patent No./Grant Date | Summary |
| 1. | Strain of Trichoderma harzianum useful as nematode inhibitor, fungicide and plant growth promoter and a process for the isolation thereof |
Alok Kalra, |
US/6475772/ 5.11.2002 | A strain of Trichoderma harzianum is obtained that is useful as a nematode inhibitor, fungicide and plant growth promoter. The strain has ATCC accession number PTA-3701. The strain is isolated by treating Trichoderma harzianum isolated from experimental fields of Central Institute of Medicinal and Aromatic Plants (CIMAP) Field Station with a mutagen such as ethyl methyl sulphonate, and isolating a whitish and fast growing strain of Trichoderma harzianum. |