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Metabolic and Structural Biology Overview | |
Research activities at the department are primarily aimed at the delineating and mechanistically describing the plant secondary metabolites related biosynthetic pathways and their steps, through structural and functional characterization of the relevant genes/ proteins/metabolites involved on important MAPs as Withania somnifera, Centella asiatica, Neem, mint and Ocimum. The ultra-modern techniques such as transcriptome mapping, RNAi, genetic transformation on one hand and on other hand conventional approaches to generate knowledge for the holistic understanding of various physiological and regulatory issues of the biogenetic processes for the commercially important metabolites are utilized. The bioinformatics aspects of molecular modeling, computational biology and chemistry, e.g., the study of molecular shape and properties, molecular simulations, protein modeling and drug design, structure activity, toxicity and property relationships, database mining and compound library design are also carried out. Crystallographic and crystal engineering studies of biologically active natural products and cytotoxic plant peptides are also pursued at the department. |
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SCIENTIST | |
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Narayan Prasad Yadav
Designation: Senior Scientist
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Phone: 0522-2718657
Field of Expertise : Phytopharmacology, Drug Delivery and Nanomedicine, Herbal Formulation
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Narendra Kumar
Designation: Scientist
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Phone: 0522-2718661
Field of Expertise : Plant Taxonomy and pharmacognosy
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Molecular & Structural Biology Achievements | |
Our recent researches have led to the significant understanding of the metabolic pathways. By utilizing systematically generated information under NIMITLI programme on ashwagandha, a superior variety of ashwagandha NMITLI 118 was developed and released. In Artemisia annua, an important anti-malarial plant, adaptation mechanism to various abiotic stresses is being pursued. The role of secondary metabolites in coping up the extreme environment imposed on them is being analysed using transcriptome versus metabolome approaches. The exploration of terpenoidal metabolome spanning entire plant growth, for important drug artemisinin and essential oil revealed differential developmental and regulation dynamics. Our group,s research interests also lie in the area of bioinformatics. We employ computational methods to elucidate intertwined relationships between protein/gene/ESTs sequences, structure, function, interactions, genome, transcriptome and pathways. The ultimate goal of our research is to obtain new, comprehensive understanding of how structures and functions are coded in molecular sequences & chemical structure and how functions of molecules are orchestrated in a cell. Specifically, we develop and apply novel computational methods for predicting protein structure from sequence, predicting protein function from sequence and structure, predicting protein-protein, protein-DNA, and protein-small molecules interactions, predicting functional sites in sequences, genome-scale function and structure annotation, transcriptome analysis, analyzing functional units in networks, structure activity relationship, structure toxicity relationship, predictive pharmacokinetics (ADME) and predictive toxicology studies. Data mining, machine learning, visualization, data and knowledge fusion, graphical interfaces etc. are all research areas for which we are developing our methods, databases and tools. We use them in practical data analytics and specialize in bioinformatics, crafting artificial intelligence approaches to answer questions from systems biology, functional genomics, metabolomics, pathways mapping and biomedicine. Total number of Publications (SCI Journals) – 150 Books chapters-5 Total number of national & international patents- 4 (1+3) |
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SCIENTIST | |
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Neelam S.Sangwan
Designation: Sr. Principal Scientist & Department Head
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 0522-2718636
Field of Expertise : Understanding and regulation of plant secondary metabolic pathways,Cloning and over-expression of key pathway
RNAi mediated gene silencing ,Biology of aroma (terpenoid) formation, Secondary metabolism under abiotic stress
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Feroz Khan Designation: Sr.Scientist
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Phone: 91- 522-2718668
Field of Expertise : Computational Drug Designing Computational Molecular Biology
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Prema G.Vasudev Designation: Sr.Scientist
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 91- 522-2718589
Field of Expertise :: Crystallographic structural studies of natural products and cytotoxic plant peptides, cystine-knot peptides, crystal
engineering of natural products.
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